Condensed Supramolecular Helices: The Twisted Sisters of DNA

IL-7 and TSLP receptors: twisted sisters.

In this issue of Blood, Shochat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP), resulting in a novel dimerization mechanism that drives acute lymphoblastic leukemias.

Cholesterol-aided supramolecular control over chromophore packing: twisted and coiled helices with distinct optical, chiroptical, and morphological features.

Condensed DNA: condensing the concepts.

DNA is stored in vivo in a highly compact, so-called condensed phase, where gene regulatory processes are governed by the intricate interplay between different states of DNA compaction. These systems often have surprising properties, which one would not predict from classical concepts of dilute solutions. The mechanistic details of DNA packing are essential for its functioning, as revealed by t...

Generalization of general helices and slant helices

In this work, we use the formal definition of $k$-slant helix cite{ali2} to obtain the intrinsic equations as well as the position vector for emph{slant-slant helices} which a generalization of emph{general helices} and emph{slant helices}. Also, we present some characterizations theorems for $k$-slant helices and derived, in general form, the intrinsic equations for such curves. Thereafter, fr...

Supramolecular Assemblies with Dna*

Information storage in chemical and biological systems involves recognition processes occurring at the molecular and macromolecular level. The implementation of a “code” can consist of multiple noncovalent interactions, which include hydrogen bonds, π-stacking, hydrophobic interactions, and appropriate molecular and supramolecular architectures. With the double-helical DNA structure stabilized ...